Robust Invalid Variance Weighted Estimator

Performs the robust invalid variance weighted estimator for Mendelian randomization.

Usage

RIVW(
  gamma.exp_sel,
  gamma.out_sel,
  se.exp_sel,
  se.out_sel,
  etamean = 0.5,
  sel.pthr = 5e-05,
  overlap.mat = NULL
)

Arguments

gamma.exp_sel

Vector of genetic associations with the exposure

gamma.out_sel

Vector of genetic associations with the outcome

se.exp_sel

Vector of standard errors for the exposure associations

se.out_sel

Vector of standard errors for the outcome associations

etamean

Mean of the random variable for re-randomization

sel.pthr

P-value threshold for selecting significant SNPs

overlap.mat

Overlap matrix for correlated samples (NULL for independent samples)

Value

A list containing the causal estimate, standard error, p-value, and number of SNPs

@export